Does assisted reproductive technology influence the complexity and associated malformations in esophageal atresia?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10503387" target="_blank" >RIV/00064203:_____/25:10503387 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10503387
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=v5YhrSYNLZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=v5YhrSYNLZ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10815-025-03624-0" target="_blank" >10.1007/s10815-025-03624-0</a>
Alternative languages
Result language
angličtina
Original language name
Does assisted reproductive technology influence the complexity and associated malformations in esophageal atresia?
Original language description
Purpose: Assisted reproductive technology (ART) has been associated with increased risks of congenital anomalies and preterm birth. However, its role in influencing the complexity of specific malformations, such as esophageal atresia (EA), remains unclear. This study aimed to assess whether ART impacts the phenotypic complexity of EA, including associated anomalies and VACTERL (vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies) association. Methods: Data from 374 EA patients enrolled in the European Pediatric Surgeons' Association (EUPSA) Esophageal Atresia Registry were analyzed. Patients were grouped based on mode of conception (28 ART and 346 natural conception) and compared for demographics, gestational age, birth weight, associated malformations, VACTERL association, and genetic disorders. Results: Gestational age and birth weight were comparable between groups (36.5 +- 3.3 vs. 36.4 +- 3.3 weeks, p = 0.42; 2412.3 +- 761.6 g vs. 2601.3 +- 744.3 g, p = 0.24). Maternal age was significantly higher in the ART group. The prevalence of cardiac, gastrointestinal, renal, musculoskeletal, and vertebral anomalies did not differ significantly. All cardiac anomalies in ART patients were minor. VACTERL association rates (25.0% vs. 18.5%, p = 0.398) and genetic disorder prevalence (7.1% vs. 4.9%, p = 0.605) were comparable. Conclusions: ART does not appear to increase the complexity of EA in terms of associated malformations, VACTERL spectrum disorders, or genetic abnormalities. Further studies with larger cohorts and detailed ART subtype data are warranted to confirm these findings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Assisted Reproduction and Genetics
ISSN
1058-0468
e-ISSN
1573-7330
Volume of the periodical
42
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
3429-3434
UT code for WoS article
001568703600001
EID of the result in the Scopus database
2-s2.0-105016810122