Impact of Muscle Paralysis After Primary Esophageal Atresia Repair
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10497815" target="_blank" >RIV/00064203:_____/25:10497815 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10497815
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xPaS4fSOj" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xPaS4fSOj</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpedsurg.2025.162361" target="_blank" >10.1016/j.jpedsurg.2025.162361</a>
Alternative languages
Result language
angličtina
Original language name
Impact of Muscle Paralysis After Primary Esophageal Atresia Repair
Original language description
BACKGROUND: Post-operative muscle paralysis aims to reduce anastomotic complications following primary esophageal atresia (EA) repair. This study evaluates the impact of paralysis on outcomes in children enrolled in the EUPSA Esophageal Atresia Registry (EAR). METHODS: Patients with type B, C, and D EA enrolled in the EAR between 2014 and 2017 who underwent primary EA repair were included. They were divided into two groups based on the use of paralysis (Group P) or not (Group NP). Comparisons included demographics, associated malformations, surgical approach, complications, and hospital stay. Multivariate logistic regressions analyses were performed. RESULTS: Of 316 patients, 126 were in Group P and 190 in Group NP. Group P had significantly lower gestational age and birth weight. Ventilation duration (7.9 +- 10.4 vs. 4.0 +- 4.4 days; p < 0.001) and hospital stay (43.7 +- 93.7 vs. 27.5 +- 31.8 days; p < 0.001) were significantly longer in Group P. The overall complication rate was higher in Group P (39.7% vs. 28.4%; p = 0.036), but mortality rates did not differ significantly. Post-operative paralysis was not associated with a significant reduction in anastomotic leaks or strictures. CONCLUSIONS: Post-operative paralysis may provide stability in high-risk cases, such as neonates with low birth weight or associated malformations, but it does not significantly reduce surgical complications and may prolong recovery. Its use should be carefully considered and limited to individualized scenarios where the benefits outweigh the risks.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pediatric Surgery
ISSN
0022-3468
e-ISSN
1531-5037
Volume of the periodical
60
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
162361
UT code for WoS article
001498392800002
EID of the result in the Scopus database
2-s2.0-105005318802