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Exhaled breath concentrations of acetic acid vapour in gastro-esophageal reflux disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F14%3A%230000434" target="_blank" >RIV/00064211:_____/14:#0000434 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388955:_____/14:00434380 RIV/00216208:11110/14:10288452 RIV/00216208:11310/14:10288452 RIV/00064165:_____/14:10288452

  • Result on the web

    <a href="http://iopscience.iop.org/article/10.1088/1752-7155/8/3/037109/meta;jsessionid=312B2D03C62CC991C65210BE718254B9.c4.iopscience.cld.iop.org" target="_blank" >http://iopscience.iop.org/article/10.1088/1752-7155/8/3/037109/meta;jsessionid=312B2D03C62CC991C65210BE718254B9.c4.iopscience.cld.iop.org</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1088/1752-7155/8/3/037109" target="_blank" >10.1088/1752-7155/8/3/037109</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Exhaled breath concentrations of acetic acid vapour in gastro-esophageal reflux disease

  • Original language description

    The objective of this experimental study was to discover volatile metabolites present in exhaled breath that could be used as biomarkers of gastro-esophageal reflux disease, GERD, one of the most common causes of chronic cough. An in vitro model based on pork tissue samples exposed to a challenge by artificial gastric fluid was used to identify specific volatile compounds to be chosen for quantification in directly exhaled breath of GERD patients and controls using selected ion flow tube mass spectrometry, SIFT-MS. GC/MS analyses of the headspace of this in vitro model indicated that the only volatile compound significantly increased was acetic acid. End expiratory concentration of acetic acid measured by SIFT-MS in mouth exhaled breath of 22 GERD patients (median 85 ppbv) was found to be significantly higher than that in breath of a control group (median 48 ppbv). Breath acetic acid may be useful for non-invasive diagnostics of GERD and other conditions resulting in the lowering of pH of the lining of the airways.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FC - Pneumology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JOURNAL OF BREATH RESEARCH

  • ISSN

    1752-7155

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    nestrankovano

  • UT code for WoS article

    000341774500014

  • EID of the result in the Scopus database