Exhaled breath concentrations of acetic acid vapour in gastro-esophageal reflux disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F14%3A%230000434" target="_blank" >RIV/00064211:_____/14:#0000434 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/14:00434380 RIV/00216208:11110/14:10288452 RIV/00216208:11310/14:10288452 RIV/00064165:_____/14:10288452
Result on the web
<a href="http://iopscience.iop.org/article/10.1088/1752-7155/8/3/037109/meta;jsessionid=312B2D03C62CC991C65210BE718254B9.c4.iopscience.cld.iop.org" target="_blank" >http://iopscience.iop.org/article/10.1088/1752-7155/8/3/037109/meta;jsessionid=312B2D03C62CC991C65210BE718254B9.c4.iopscience.cld.iop.org</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1752-7155/8/3/037109" target="_blank" >10.1088/1752-7155/8/3/037109</a>
Alternative languages
Result language
angličtina
Original language name
Exhaled breath concentrations of acetic acid vapour in gastro-esophageal reflux disease
Original language description
The objective of this experimental study was to discover volatile metabolites present in exhaled breath that could be used as biomarkers of gastro-esophageal reflux disease, GERD, one of the most common causes of chronic cough. An in vitro model based on pork tissue samples exposed to a challenge by artificial gastric fluid was used to identify specific volatile compounds to be chosen for quantification in directly exhaled breath of GERD patients and controls using selected ion flow tube mass spectrometry, SIFT-MS. GC/MS analyses of the headspace of this in vitro model indicated that the only volatile compound significantly increased was acetic acid. End expiratory concentration of acetic acid measured by SIFT-MS in mouth exhaled breath of 22 GERD patients (median 85 ppbv) was found to be significantly higher than that in breath of a control group (median 48 ppbv). Breath acetic acid may be useful for non-invasive diagnostics of GERD and other conditions resulting in the lowering of pH of the lining of the airways.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FC - Pneumology
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF BREATH RESEARCH
ISSN
1752-7155
e-ISSN
—
Volume of the periodical
8
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
nestrankovano
UT code for WoS article
000341774500014
EID of the result in the Scopus database
—