Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F19%3AM0000102" target="_blank" >RIV/00064211:_____/19:M0000102 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10396330 RIV/00216208:11150/19:10396330 RIV/00179906:_____/19:10396330 RIV/00064165:_____/19:10396330 RIV/00064211:_____/19:W0002031

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pubmed/30675285/" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/30675285/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ol.2018.9855" target="_blank" >10.3892/ol.2018.9855</a>

Result language

angličtina

Original language name

Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases

Original language description

The criteria for distinction between independent primary tumors and metastasis from one site to the other in synchronous endometrioid endometrial and ovarian carcinoma (SEO) has been a matter of dispute for a long time. In our study we performed a comprehensive clinico-pathological and molecular analysis of 22 cases of SEO. Based on conventional clinico-pathological criteria the cases were classified as independent primary tumors (10 cases) and metastasis from one location to the other (12 cases). All tumors were analyzed by NGS with a panel of 73 genes (219 kbp). Clonal origin was confirmed in all cases by at least one shared mutation in and . Two patients carried germline pathogenic mutation in cancer-predisposing genes or . Microsatellite instable phenotype was detected in 5/22 (22.7%) SEO, but in one case only in the endometrial tumor. In conclusion, our results showed that all 22 SEOs were clonally related, irrespectively of their clinico-pathological features. Even low grade and low stage tumors classified as independent primaries, according to the conventional morphological criteria, have a clonal origin. From the practical point of view, only the conventional morphological criteria should be used for the classification (staging) of these tumors. However, molecular profiling of these tumors may have prognostic and predictive meaning.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology letters

ISSN

1792-1074

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

2

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

2207-2214

UT code for WoS article

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EID of the result in the Scopus database

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