Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F19%3AW0002031" target="_blank" >RIV/00064211:_____/19:W0002031 - isvavai.cz</a>
Alternative codes found
RIV/00064211:_____/19:M0000102 RIV/00216208:11110/19:10396330 RIV/00216208:11150/19:10396330 RIV/00179906:_____/19:10396330 RIV/00064165:_____/19:10396330
Result on the web
<a href="https://oadoi.org/10.3892/ol.2018.9855" target="_blank" >https://oadoi.org/10.3892/ol.2018.9855</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ol.2018.9855" target="_blank" >10.3892/ol.2018.9855</a>
Alternative languages
Result language
angličtina
Original language name
Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases
Original language description
The criteria for distinction between independent primary tumors and metastasis from one site to the other in synchronous endometrioid endometrial and ovarian carcinoma (SEO) has been a matter of dispute for a long time. In our study we performed a comprehensive clinico-pathological and molecular analysis of 22 cases of SEO. Based on conventional clinico-pathological criteria the cases were classified as independent primary tumors (10 cases) and metastasis from one location to the other (12 cases). All tumors were analyzed by NGS with a panel of 73 genes (219 kbp). Clonal origin was confirmed in all cases by at least one shared mutation in PTEN, AKT1, PIK3CA, KRAS, TP53 and ARID1A. Two patients carried germline pathogenic mutation in cancer-predisposing genes BRCA1 or BARD1. Microsatellite instable phenotype was detected in 5/22 (22.7%) SEO, but in one case only in the endometrial tumor. In conclusion, our results showed that all 22 SEOs were clonally related, irrespectively of their clinico-pathological features. Even low grade and low stage tumors classified as independent primaries, according to the conventional morphological criteria, have a clonal origin. From the practical point of view, only the conventional morphological criteria should be used for the classification (staging) of these tumors. However, molecular profiling of these tumors may have prognostic and predictive meaning.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ONCOLOGY LETTERS
ISSN
1792-1074
e-ISSN
1792-1082
Volume of the periodical
17
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
8
Pages from-to
2207-2214
UT code for WoS article
000459551800099
EID of the result in the Scopus database
2-s2.0-85059644182