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Long-term results of postoperative and definitive (chemo) radiotherapy in sinonasal carcinoma. Adult Comorbidity Evaluation 27 score as a predictor of survival

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F23%3AW0000027" target="_blank" >RIV/00064211:_____/23:W0000027 - isvavai.cz</a>

  • Result on the web

    <a href="https://oadoi.org/10.5603/RPOR.a2023.0017" target="_blank" >https://oadoi.org/10.5603/RPOR.a2023.0017</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5603/RPOR.a2023.0017" target="_blank" >10.5603/RPOR.a2023.0017</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Long-term results of postoperative and definitive (chemo) radiotherapy in sinonasal carcinoma. Adult Comorbidity Evaluation 27 score as a predictor of survival

  • Original language description

    Background: The objective was to evaluate the efficacy and toxicity of curative radiotherapy in patients with sinonasal carcinoma and to identify prognostic factors influencing treatment outcomes. Materials and methods: The authors conducted a retrospective study of 61 consecutive patients treated with postoperative or definitive radiotherapy from 2002 to 2018 (median age 59 years, current/former smokers 71%, maxillary sinus 67%, nasal cavity 26%). The majority of patients were diagnosed with locally advanced disease (85% clinical stage & GE; III). Regional cervical metastases were initially diagnosed in 23% of patients. The most common histology was squamous cell carcinoma (61%). Radiation therapy was preceded by radical surgery in 64% of patients. 29 patients received chemotherapy (48%). Results: The median follow-up was 53 months. The median total dose of radiotherapy achieved was 70 Gy. The 5- and 10-year locoregional control, distant control, overall survival, and disease-free survival were 74% and 64%, 90% and 90%, 51% and 35%, and 38% and 25%, respectively. Severe acute toxicity occurred in 36%, severe late toxicity in 23% of patients. Severe unilateral visual impairment occurred in 6 patients, temporal lobe necrosis in 1 patient, and osteoradionecrosis requiring surgery in 2 patients. Conclusion: The results of the study demonstrated the high effectiveness of curative treatment in patients with sinonasal carcinoma with long-term locoregional and distant control. The multivariate analysis indicated that N-staging, age, comorbidity score [as assessed by Adult Comorbidity Evaluation 27 (ACE-27)] and initial response to treatment were the strongest prognostic factors.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY

  • ISSN

    1507-1367

  • e-ISSN

    2083-4640

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    PL - POLAND

  • Number of pages

    12

  • Pages from-to

    147-158

  • UT code for WoS article

    001028897300001

  • EID of the result in the Scopus database

    2-s2.0-85166338614