Evaluation of Polymeric Micro/Nanofibrous Hybrid Scaffolds Prepared via Centrifugal Nozzleless Spinning for Tissue Engineering Applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F25%3AW0000049" target="_blank" >RIV/00064211:_____/25:W0000049 - isvavai.cz</a>

Result on the web

<a href="https://oadoi.org/10.3390/polym17030386" target="_blank" >https://oadoi.org/10.3390/polym17030386</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/polym17030386" target="_blank" >10.3390/polym17030386</a>

Result language

angličtina

Original language name

Evaluation of Polymeric Micro/Nanofibrous Hybrid Scaffolds Prepared via Centrifugal Nozzleless Spinning for Tissue Engineering Applications

Original language description

We compared the applicability of 3D fibrous scaffolds, produced by our patented centrifugal spinning technology, in soft tissue engineering. The scaffolds were prepared from four different biocompatible and biodegradable thermoplastics, namely, polylactide (PLA), polycaprolactone (PCL), poly(3-hydroxybutyrate) (PHB), and poly(1,4-butylene succinate) (PBS) and their blends. The combined results of SEM and BET analyses revealed an internal hierarchically organized porosity of the polymeric micro/nanofibers. Both nanoporosity and capillary effect are crucial for the water retention capacity of scaffolds designed for tissue engineering. The increased surface area provided by nanoporosity enhances water retention, while the capillary effect facilitates the movement of water and nutrients within the scaffolds. When the scaffolds were seeded with adipose-derived stem cells (ASCs), the ingrowth of these cells was the deepest in the PLA/PCL 13.5/4 (w/w) composite scaffolds. This result is consistent with the relatively large pore size in the fibrous networks, the high internal porosity, and the large specific surface area found in these scaffolds, which may therefore be best suited as a component of adipose tissue substitutes that could reduce postoperative tissue atrophy. Adipose tissue constructs produced in this way could be used in the future instead of conventional fat grafts, for example, in breast reconstruction following cancer ablation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

POLYMERS

ISSN

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e-ISSN

2073-4360

Volume of the periodical

17

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

30

Pages from-to

-

UT code for WoS article

001418377400001

EID of the result in the Scopus database

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