Immunohistochemical expression of GPNMB in TFEB-rearranged and TFEB-amplified renal cell carcinomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F26%3AW0000086" target="_blank" >RIV/00064211:_____/26:W0000086 - isvavai.cz</a>
Result on the web
<a href="https://oadoi.org/10.1007/s00428-026-04466-6" target="_blank" >https://oadoi.org/10.1007/s00428-026-04466-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-026-04466-6" target="_blank" >10.1007/s00428-026-04466-6</a>
Alternative languages
Result language
angličtina
Original language name
Immunohistochemical expression of GPNMB in TFEB-rearranged and TFEB-amplified renal cell carcinomas
Original language description
TFEB-altered renal cell carcinomas (RCCs) display a wide range of morphological features and variable immunohistochemical profiles, often overlapping with other RCC subtypes. This variability poses significant diagnostic challenges. Consequently, there is an ongoing search for reliable ancillary tests that can aid in identifying cases that warrant molecular testing. In this study, we focused on GPNMB immunohistochemistry expression in TFEB-rearranged and TFEB-amplified RCCs. A total of 25 TFEB-altered RCCs, including 16 TFEB-amplified RCCs and nine TFEB-rearranged RCCs, were included in the study. GPNMB immunohistochemistry was positive in all nine TFEB-rearranged RCCs, demonstrating strong, diffuse cytoplasmic staining. In the TFEB-amplified RCC cohort, GPNMB expression was also detected in all 16 tumors; however, the staining pattern differed from that seen in TFEB-rearranged RCCs. Diffuse staining was observed in eight tumors (50%), four of which showed variable staining intensity, while the remaining eight tumors (50%) exhibited focal GPNMB reactivity, with intervening negative areas. GPNMB was therefore positive in all 25/25 (100%) TFEB-altered RCCs by IHC, supporting its potential role as a sensitive screening marker for such RCCs. TFEB-rearranged RCCs typically exhibited strong, diffuse GPNMB immunoreactivity, whereas TFEB-amplified RCCs more often showed patchy or focal staining of lower intensity, interspersed with areas of GPNMB negativity. Variability of staining in TFEB-amplified RCCs underscores the need for cautious interpretation, particularly in limited biopsy specimens, taking into account the morphologic findings and other immunohistochemistry stains, such as Melan A and Cathepsin K.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2026
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
VIRCHOWS ARCHIV
ISSN
0945-6317
e-ISSN
1432-2307
Volume of the periodical
neuveden
Issue of the periodical within the volume
18 February 2026
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
nestrankovano
UT code for WoS article
001705999300001
EID of the result in the Scopus database
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