Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00092584%3A_____%2F17%3AN0000001" target="_blank" >RIV/00092584:_____/17:N0000001 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/BCO.0000000000000457" target="_blank" >http://dx.doi.org/10.1097/BCO.0000000000000457</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/BCO.0000000000000457" target="_blank" >10.1097/BCO.0000000000000457</a>
Alternative languages
Result language
angličtina
Original language name
Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid
Original language description
Background: The objective of the present study was to determine if platelet rich plasma (PRP) can increase tibiofemoral cartilage regeneration and improve knee function. Methods: Fourty consecutive and strictly selected patients affected by grade II or III chondromalacia underwent 1 yr of treatment (nine injections) with autologous PRP in a liquid form with 2.0 to 2.5-fold platelet concentration (20 cases) or with hyaluronic acid (HA) (20 patients). Outcome measures included the Lysholm, Tegner, International Knee Documentation Committee (IKDC), Western Ontario and McMaster (WOMAC) Osteoarthritis Index, and Short Form (SF)-36 scores. MRI arthroscopic and histologic assessment were used to evaluate cartilage thickness and degree of degeneration before and after treatment (1 yr after the primary arthroscopy). Results: The study demonstrated significant improvement in Lysholm, Tegner, IKDC, WOMAC, and SF-36 scores in both groups. Cartilage assessment revealed no significant macroscopic or microscopic structural regeneration as well as no cartilage height increase in either group. Higher content of chondrocytes and proteoglycans in cartilage was proven in both groups after treatment without a statistically significant difference between the groups. There were no adverse events observed. Conclusions: PRP and HA significantly reduced pain and improved quality of life in patients with a low degree of cartilage degeneration. MRI and arthroscopic assessment did not confirm any significant cartilage structural improvement. The content of chondrocytes and proteoglycans in cartilage was higher in the PRP group than in the HA group after the treatment but did not reach statistical significance.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FI - Traumatology and orthopaedics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT12057" target="_blank" >NT12057: Platelet-rich plasma in treatment of the chondropathy of the knee joint</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Orthopaedic Practice
ISSN
1940-7041
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
58-65
UT code for WoS article
000399086100012
EID of the result in the Scopus database
2-s2.0-85011396273