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Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00092584%3A_____%2F17%3AN0000001" target="_blank" >RIV/00092584:_____/17:N0000001 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1097/BCO.0000000000000457" target="_blank" >http://dx.doi.org/10.1097/BCO.0000000000000457</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/BCO.0000000000000457" target="_blank" >10.1097/BCO.0000000000000457</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tibiofemoral chondromalacia treated with platelet-rich plasma and hyaluronic acid

  • Original language description

    Background: The objective of the present study was to determine if platelet rich plasma (PRP) can increase tibiofemoral cartilage regeneration and improve knee function. Methods: Fourty consecutive and strictly selected patients affected by grade II or III chondromalacia underwent 1 yr of treatment (nine injections) with autologous PRP in a liquid form with 2.0 to 2.5-fold platelet concentration (20 cases) or with hyaluronic acid (HA) (20 patients). Outcome measures included the Lysholm, Tegner, International Knee Documentation Committee (IKDC), Western Ontario and McMaster (WOMAC) Osteoarthritis Index, and Short Form (SF)-36 scores. MRI arthroscopic and histologic assessment were used to evaluate cartilage thickness and degree of degeneration before and after treatment (1 yr after the primary arthroscopy). Results: The study demonstrated significant improvement in Lysholm, Tegner, IKDC, WOMAC, and SF-36 scores in both groups. Cartilage assessment revealed no significant macroscopic or microscopic structural regeneration as well as no cartilage height increase in either group. Higher content of chondrocytes and proteoglycans in cartilage was proven in both groups after treatment without a statistically significant difference between the groups. There were no adverse events observed. Conclusions: PRP and HA significantly reduced pain and improved quality of life in patients with a low degree of cartilage degeneration. MRI and arthroscopic assessment did not confirm any significant cartilage structural improvement. The content of chondrocytes and proteoglycans in cartilage was higher in the PRP group than in the HA group after the treatment but did not reach statistical significance.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FI - Traumatology and orthopaedics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT12057" target="_blank" >NT12057: Platelet-rich plasma in treatment of the chondropathy of the knee joint</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Orthopaedic Practice

  • ISSN

    1940-7041

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    58-65

  • UT code for WoS article

    000399086100012

  • EID of the result in the Scopus database

    2-s2.0-85011396273