Grey wolf genomic history reveals a dual ancestry of dogs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00094862%3A_____%2F22%3AN0000197" target="_blank" >RIV/00094862:_____/22:N0000197 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41586-022-04824-9" target="_blank" >https://www.nature.com/articles/s41586-022-04824-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41586-022-04824-9" target="_blank" >10.1038/s41586-022-04824-9</a>
Alternative languages
Result language
angličtina
Original language name
Grey wolf genomic history reveals a dual ancestry of dogs
Original language description
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived1,2,3,4,5,6,7,8. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature
ISSN
0028-0836
e-ISSN
1476-4687
Volume of the periodical
607
Issue of the periodical within the volume
7918
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
313-320
UT code for WoS article
000818664800008
EID of the result in the Scopus database
2-s2.0-85133199579