Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F12%3A%230000333" target="_blank" >RIV/00098892:_____/12:#0000333 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia
Original language description
We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-?) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The medianfollow-up was 82.6 months (range 12.4?212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7?40.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase?polymerase chain reaction [?complete? molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4?10) years, while 2 continue with IFN-? and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01?0.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite conti
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)