Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33117915" target="_blank" >RIV/61989592:15110/13:33117915 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/13:#0000486

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2012.068" target="_blank" >http://dx.doi.org/10.5507/bp.2012.068</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2012.068" target="_blank" >10.5507/bp.2012.068</a>

Result language

angličtina

Original language name

Interferon-alpha in chronic myeloid leukemia revisited: a long-term retrospective study in Central and Northern Moravia

Original language description

Aims We assessed long-term outcome of consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (INF-?) in Central and Northern Moravia between 1989 and 2006. Methods A retrospective study focused on the response, prognostic factors and side effects of INF-?. Results 118 patients (67 males and 51 females at a median age 50 years; range 18-71) were analyzed. The median follow-up was 82.6 months (12.4-212.6). Thirty-six patients (30.5%) achieved major cytogenetic response (CyR) in median of 18.3 months (3.7-47.3) and maintained it for median of 64.0 months (7.0-176.0). Sixty-one patients treated with INF-? for more than 12 months had overall survival (OS) 137.0 months (95% CI 117.6-156.4). Eighteen (29.5%) of them achieved complete CyR (CCyR). 109 patients discontinued the treatment with INF-? because of hematologic or cytogenetic resistance in 53 (48.7%), progression of CML in 31 (28.4%) and intolerance to INF-? in 17 (15.6%) patients. The per

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Volume of the periodical

157

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

248-256

UT code for WoS article

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EID of the result in the Scopus database

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