Clinical Potential of Effective Noninvasive Exclusion of KEL1-Positive Fetuses in KEL1-Negative Pregnant Women

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F15%3A%230000932" target="_blank" >RIV/00098892:_____/15:#0000932 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Clinical Potential of Effective Noninvasive Exclusion of KEL1-Positive Fetuses in KEL1-Negative Pregnant Women
Original language description
In pregnant women diagnosed with blood cell alloantibody anti-K (K-negative, genotype KEL2/KEL2), the fetuses are at risk of hemolytic disease only if antigen ´K´´(´K´-positive, genotype KEL1/KEL2) is present on their erythrocytes. In reality, however, approximately 95 % of fetuses are ´K´-negative (genotype KEL2/KEL2) and this are not at risk of hemolytic disease . The clinical importance of assessing the fetal KEL genotype is to exclude ´K´-negative fetuses (genotype KEL2/KEL2) in ´K´-negative pregnant women. Maternal anti-K antibodies that penetrate through the placenta during incompatible pregnancy cause suppression of erythropoiesis.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/NT12225" target="_blank" >NT12225: Determining fetal RHD and KELL genotype from peripheral blood of pregnant women</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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