Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F16%3AN0000046" target="_blank" >RIV/00098892:_____/16:N0000046 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/16:10319136 RIV/61989592:15110/16:33160396 RIV/00179906:_____/16:10319136

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation

Original language description

Background: Gastrointestinal toxicity is the principal toxicity of chemoradiation in the treatment of rectal carcinoma. The assessment of this toxicity still relies mostly on the symptoms reported by the patient. Methods: Plasma citrulline, serum neopterin and urinary neopterin were followed weekly in 49 patients with rectal carcinoma during chemoradiation. Results: Citrulline significantly (p < 0.05) decreased while serum and urinary neopterin concentrations increased during therapy. Irradiated gut volume correlated significantly inversely with citrulline and positively with urinary neopterin. Statistically significant inverse correlations were also observed between urinary neopterin and plasma citrulline concentrations during the treatment. Urinary neopterin concentrations were significantly higher and citrulline concentrations were lower in patients who experienced grade >= 3 gastrointestinal toxicity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Chemistry and Laboratory Medicine

ISSN

1434-6621

e-ISSN

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Volume of the periodical

54

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

305-314

UT code for WoS article

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EID of the result in the Scopus database

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