The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic importance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F16%3AN0000059" target="_blank" >RIV/00098892:_____/16:N0000059 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/16:33160908

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic importance

Original language description

Aims. To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters Methods. MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffinembedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis. Results. Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients. Conclusion. A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

<a href="/en/project/NT13701" target="_blank" >NT13701: Expression of vascular endothelial growth factor VEGF-C/D and its significance for lymphangioneogenesis, nodal metastase and prognosis of salivary gland carcinomas.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Volume of the periodical

160

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

417-422

UT code for WoS article

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EID of the result in the Scopus database

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