Small subset of adenoid cystic carcinoma of the skin is associated with alterations of the MYBL1 gene similar to their extracutaneous counterparts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10381712" target="_blank" >RIV/00216208:11110/18:10381712 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/18:10381712 RIV/00064165:_____/18:10381712
Result on the web
<a href="https://insights.ovid.com/crossref?an=00000372-201810000-00002" target="_blank" >https://insights.ovid.com/crossref?an=00000372-201810000-00002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/DAD.0000000000001091" target="_blank" >10.1097/DAD.0000000000001091</a>
Alternative languages
Result language
angličtina
Original language name
Small subset of adenoid cystic carcinoma of the skin is associated with alterations of the MYBL1 gene similar to their extracutaneous counterparts
Original language description
Adenoid cystic carcinoma (ACC) of the skin is a rare malignant neoplasm histologically identical to homonymous tumors in other organs. Cutaneous ACC has been found to harbor MYB gene activations, either through MYB chromosomal abnormalities or by generation of the MYB-NFIB fusion. In salivary gland ACC, in addition to the MYB gene, alterations in MYBL1, the gene closely related to MYB, have been reported. We studied 10 cases of cutaneous ACC (6 women, 4 men; and age range 51-83 years) for alterations in the MYB, NFIB, and MYBL1 genes, using FISH and PCR. MYB break-apart and NFIB break-apart tests were positive in 4 and 5 cases, respectively. MYB-NFIB fusions were found in 4 cases. The break of MYBL1 was found in 2 cases, and in one of them, the NFIB break-apart probe was positive, strongly indicating a MYBL1-NFIB fusion. In 2 cases, the MYB break-apart test was positive, whereas no MYB-NFIB was detected, strongly suggesting another fusion partner. It is concluded that MYBL1 alterations are detected in primary cutaneous ACC but are apparently less common compared with MYB and NFIB alterations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The American Journal of Dermatopathology
ISSN
0193-1091
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
721-726
UT code for WoS article
000451234000007
EID of the result in the Scopus database
2-s2.0-85060314906