Lack of deletion of 1p36 in 8 cases of primary adenoid cystic carcinoma of the skin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F19%3A10399084" target="_blank" >RIV/00216208:11140/19:10399084 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EpBfhdZC1_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=EpBfhdZC1_</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/DAD.0000000000001294" target="_blank" >10.1097/DAD.0000000000001294</a>
Alternative languages
Result language
angličtina
Original language name
Lack of deletion of 1p36 in 8 cases of primary adenoid cystic carcinoma of the skin
Original language description
In our previous study, we have demonstrated that primary cutaneous adenoid cystic carcinoma (ACC) manifests genetic changes similar to its salivary gland homologue, including alterations in the MYB and MYBL1 genes.1 Deletion of the 1p36 locus has been shown in salivary gland ACC (range of detection: 0%-44%),2-4 in which this alteration has been found to be associated with reduced overall survival, higher tumor stage, lower recurrence-free interval, lower recurrence-free survival, solid histology, and the absence of MYBL1 break.4,5 As this technique has now become available for us, we investigated our previously published cohort of 10 patients with primary cutaneous ACC.1 FISH for 1p36 was performed, as described elsewhere.5 The analysis was successful in 8 of the 10 cutaneous neoplasms. All the cases, including 2 patients who died of metastatic disease, proved negative. It seems that the deletion of 1p36 is not a feature of cutaneous ACC, but further studies on larger series are needed to confirm this assumption.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The American Journal of Dermatopathology
ISSN
0193-1091
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
2
Pages from-to
781-782
UT code for WoS article
000509675000021
EID of the result in the Scopus database
2-s2.0-85072745591