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Associations between homeostasis model assessment (HOMA) and routinely examined parameters in individuals with metabolic syndrome

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000008" target="_blank" >RIV/00098892:_____/19:N0000008 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10402778 RIV/61989592:15110/19:73595569

  • Result on the web

    <a href="http://www.biomed.cas.cz/physiolres/pdf/68/68_921.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/68/68_921.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.33549/physiolres.934141" target="_blank" >10.33549/physiolres.934141</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Associations between homeostasis model assessment (HOMA) and routinely examined parameters in individuals with metabolic syndrome

  • Original language description

    The aim of the study was to investigate whether routine clinical parameters, including visceral adiposity index (VAI) and atherogenic index of plasma (AIP), could become widely applicable predictors of insulin resistance (IR), evaluated using homeostasis model assessment (HOMA-IR, HOMA-beta), with regard to presence of metabolic syndrome (MS). The study comprised 188 individuals identified to meet the MS criteria during regular health examinations and an equal number of age, sex-matched controls without MS. The strongest correlations were noted between HOMA-IR and waist circumference (WC) in the MS group (r=0.57) as well as between HOMA-IR and alanine aminotransferase (ALT, r=0.57) or aspartate aminotransferase (r=0.56) in the controls, with a statistical significance of p<0.001. In a multivariate linear regression model, the predictors of HOMA-IR were WC (linear coefficient beta=0.1, p<0.001), ALT (beta=2.28, p<0.001) and systolic blood pressure (beta=0.04, p<0.001). HOMA-beta was determined by WC (beta=1.97, p=0.032) and ALT (beta=99.49, p=0.004) and inversely associated with age (beta=-1.31, p=0.004). Neither VAI nor AIP were significant predictors. The presence of MS was significantly associated with both HOMA-IR and HOMA-beta. These results indicate that WC and ALT appear to be reliable predictors of IR. Comprehensive assessment of these parameters may serve for estimating the level of IR.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30302 - Epidemiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PHYSIOLOGICAL RESEARCH

  • ISSN

    0862-8408

  • e-ISSN

    1802-9973

  • Volume of the periodical

    68

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    10

  • Pages from-to

    921-930

  • UT code for WoS article

    000505181300006

  • EID of the result in the Scopus database

    2-s2.0-85077401942