Associations between homeostasis model assessment (HOMA) and routinely examined parameters in individuals with metabolic syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000008" target="_blank" >RIV/00098892:_____/19:N0000008 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10402778 RIV/61989592:15110/19:73595569
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/68/68_921.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/68/68_921.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934141" target="_blank" >10.33549/physiolres.934141</a>
Alternative languages
Result language
angličtina
Original language name
Associations between homeostasis model assessment (HOMA) and routinely examined parameters in individuals with metabolic syndrome
Original language description
The aim of the study was to investigate whether routine clinical parameters, including visceral adiposity index (VAI) and atherogenic index of plasma (AIP), could become widely applicable predictors of insulin resistance (IR), evaluated using homeostasis model assessment (HOMA-IR, HOMA-beta), with regard to presence of metabolic syndrome (MS). The study comprised 188 individuals identified to meet the MS criteria during regular health examinations and an equal number of age, sex-matched controls without MS. The strongest correlations were noted between HOMA-IR and waist circumference (WC) in the MS group (r=0.57) as well as between HOMA-IR and alanine aminotransferase (ALT, r=0.57) or aspartate aminotransferase (r=0.56) in the controls, with a statistical significance of p<0.001. In a multivariate linear regression model, the predictors of HOMA-IR were WC (linear coefficient beta=0.1, p<0.001), ALT (beta=2.28, p<0.001) and systolic blood pressure (beta=0.04, p<0.001). HOMA-beta was determined by WC (beta=1.97, p=0.032) and ALT (beta=99.49, p=0.004) and inversely associated with age (beta=-1.31, p=0.004). Neither VAI nor AIP were significant predictors. The presence of MS was significantly associated with both HOMA-IR and HOMA-beta. These results indicate that WC and ALT appear to be reliable predictors of IR. Comprehensive assessment of these parameters may serve for estimating the level of IR.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30302 - Epidemiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PHYSIOLOGICAL RESEARCH
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
68
Issue of the periodical within the volume
6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
921-930
UT code for WoS article
000505181300006
EID of the result in the Scopus database
2-s2.0-85077401942