Can visceral adiposity index serve as a simple tool for identifying individuals with insulin resistance in daily clinical practice?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000040" target="_blank" >RIV/00098892:_____/19:N0000040 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/19:73595570
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780575/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780575/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/medicina55090545" target="_blank" >10.3390/medicina55090545</a>
Alternative languages
Result language
angličtina
Original language name
Can visceral adiposity index serve as a simple tool for identifying individuals with insulin resistance in daily clinical practice?
Original language description
Background and objectives: The visceral adiposity index (VAI), estimating visceral adiposity dysfunction through a simple formula, could serve as a useful tool for identifying individuals at higher cardiometabolic risk. Its relationship with insulin resistance (IR), assessed using the homeostasis model assessment of IR (HOMA-IR), and metabolic syndrome (MetS) components remains unclear. The study aimed to investigate the association of VAI with both HOMA-IR and MetS. Materials and Methods: After undergoing anthropometric and biochemical studies, 783 individuals were divided into three groups according to a number of present MetS components. The VAI cut-offs signaling MetS and HOMA-IR were determined by maximizing the sum of the sensitivity and specificity. Correlation analysis was performed to explore the associations between VAI and other tested parameters. A logistic stepwise regression analysis was applied to identify statistically significant determinants of HOMA-IR. Given the variability of reference values, two thresholds of HOMA-IR were applied, namely 2.0 and 3.8. Results: VAI increased significantly between the groups with a rising number of MetS components. The VAI cut-off for MetS was 2.37, with a sensitivity of 0.86 and a specificity of 0.78. The same cut-off point identified subjects with HOMA-IR = 3.8, with a sensitivity of 0.79 and a specificity of 0.66. The VAI cut-off for HOMA-IR = 2.0 was 1.89, with a sensitivity of 0.74 and a specificity of 0.68. The strongest correlations of VAI were noted with HOMA-IR (r = 0.51) and insulin (r = 0.49), respectively, while the strongest correlation of HOMA-IR was with waist circumference (r = 0.54). Not one of the routine parameters was a significant predictor in the regression analysis. Conclusions: The obtained results show an existing association of VAI with HOMA-IR. The high sensitivity and specificity of the cut-offs may allow the application of VAI in common clinical practice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30302 - Epidemiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicina-Lithuania
ISSN
1010-660X
e-ISSN
1648-9144
Volume of the periodical
55
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
545
UT code for WoS article
000490752800038
EID of the result in the Scopus database
2-s2.0-85071747677