Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000027" target="_blank" >RIV/00098892:_____/19:N0000027 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/19:73594617
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607215/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607215/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ol.2019.10447" target="_blank" >10.3892/ol.2019.10447</a>
Alternative languages
Result language
angličtina
Original language name
Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine
Original language description
Sphingosine 1‑phosphate (S1P) is a bioactive lipid metabolite associated with cancer cell proliferation, survival, migration and regulation of tumor angiogenesis in various cellular and animal models. Sphingosine kinase‑1 (SphK1) and S1P lyase are the main enzymes that respectively control the synthesis and degradation of S1P. The present study analyzed the prognostic and predictive value of SphK1 and S1P lyase expression in patients with non‑small cell lung cancer (NSCLC), treated with either surgery alone or in combination with adjuvant carboplatin and navelbine. Formalin‑fixed, paraffin‑embedded tissue samples from 176 patients with NSCLC were stained immunohistochemically using antibodies against SphK1 and S1P lyase, and their expression was correlated with all available clinicopathological factors. Increased expression of SphK1 was significantly associated with shorter overall and disease free survival in patients treated with adjuvant platinum‑based chemotherapy. No prognostic relevance for S1P lyase expression was observed. Collectively, the results suggest that the immunohistochemical detection of SphK1 may be a promising predictive marker in NSCLC patients treated with adjuvant platinum‑based chemotherapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncology Letters
ISSN
1792-1074
e-ISSN
1792-1082
Volume of the periodical
18
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
8
Pages from-to
1259-1266
UT code for WoS article
000476990900031
EID of the result in the Scopus database
2-s2.0-85069967471