Modulatory effect of the Euro‑Lupus low‑dose intravenous cyclophosphamide regimen on circulating immune cells in systemic lupus erythematosus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000043" target="_blank" >RIV/00098892:_____/19:N0000043 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/19:73595606

Result on the web

<a href="https://link.springer.com/article/10.1007/s00005-019-00563-4" target="_blank" >https://link.springer.com/article/10.1007/s00005-019-00563-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00005-019-00563-4" target="_blank" >10.1007/s00005-019-00563-4</a>

Result language

angličtina

Original language name

Modulatory effect of the Euro‑Lupus low‑dose intravenous cyclophosphamide regimen on circulating immune cells in systemic lupus erythematosus

Original language description

A Euro-Lupus regimen of low-dose intravenous cyclophosphamide (CFA) is commonly used to treat severe organ manifestations of systemic lupus erythematosus (SLE), particularly lupus nephritis (LN). There are no data on the distributions and dynamics of immune cell populations in patients with various treatment outcomes. The circulating immune cells of 11 female SLE patients were assessed before and after Euro-Lupus regimen (cumulative dose of 3000 mg CFA) by flow cytometry together with those of 16 healthy women. A subanalysis was performed in LN patients who achieved complete remission (CR; n = 3), partial remission (PR; n = 4), and no response (NR; n = 2). In SLE, the Euro-Lupus regimen decreased the percentage and absolute count of B cells; increased the percentage of CD8+ T cells, T regulatory cells, neutrophils, and monocyte subsets; and activated T and NK cells compared to healthy controls (P < 0.050). Patients with LN achieving CR had significantly lower proportions of CD27+ B memory cells compared to poor responders (PR/NR, P = 0.035). The post-treatment percentages and absolute numbers of B cells, T cells, NK cells, monocytes, and neutrophils showed high inter-individual variability with no association with treatment outcome. Our pilot study revealed the dynamics of changes in immune cell populations in SLE patients during a Euro-Lupus regimen, mainly the lowering of B cells. In LN patients who achieved CR, a lower proportion of CD27+ B memory cells was evident compared to poor responders (PR/NR). Further studies on usefulness of monitoring immune cells for treatment response prediction on larger cohorts are needed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30226 - Rheumatology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

ISSN

0004-069X

e-ISSN

1661-4917

Volume of the periodical

67

Issue of the periodical within the volume

6

Country of publishing house

PL - POLAND

Number of pages

11

Pages from-to

415-425

UT code for WoS article

000490648300001

EID of the result in the Scopus database

2-s2.0-85074070084