Effect of different types of extracorporeal circulation on hemostasis activation and methods for its monitoring

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000158" target="_blank" >RIV/00098892:_____/19:N0000158 - isvavai.cz</a>
Result on the web
<a href="https://biomedres.us/fulltexts/BJSTR.MS.ID.003039.php" target="_blank" >https://biomedres.us/fulltexts/BJSTR.MS.ID.003039.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.26717/BJSTR.2019.17.003039" target="_blank" >10.26717/BJSTR.2019.17.003039</a>

Result language
angličtina
Original language name
Effect of different types of extracorporeal circulation on hemostasis activation and methods for its monitoring
Original language description
Extracorporeal circulation is associated with complex activation of all components of hemostasis, the causes of which are multifactorial: surgical trauma, loss of vascular integrity, contact with non-endothelial surface, non-pulsatile flow, hypothermia, systemic inflammatory response, numerous drugs, and other. A key component of haemostasis activation is the excessive generation of tissue factor leading to the formation of thrombin to physiologically prevent bleeding. The report presents an overview and description of experimental methodologies with an emphasis on monitor the effect of each type of extracorporeal circulation, monitoring of thrombin generation, as the initiator of all cagulation reactions, including platelet activation.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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