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Spektroskopická charakterizace aptasenzoru specifického pro thrombin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00058010" target="_blank" >RIV/00216224:14740/12:00058010 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Spektroskopická charakterizace aptasenzoru specifického pro thrombin

  • Original language description

    Gold nanoparticles (GNPs) represent a very attractive material for the construction of sensors and biosensors with immobilized aptamer on the surface, due to their biocompatibility. The most extensively studied aptamer is the thrombin binding aptamer (TBA) with sequence GGT TGG TGT GGT TGG, specifically binding to thrombin, and thus inhibits the activity of thrombin in the cascade of reactions resulting in the hemocoagulation. The aim of our contribution is spectroscopic characterization of aptasensor system and verify its specificity to thrombin in buffered and non ? buffered aqueous solutions with adjusted ionic strength. For our experiment the GNPs (5, 10 and 20nm) stabilized in citrate buffer were used. The absorption spectra were monitored not only in the dependence on particles size, but also on the components of used solutions. For the detection of aggregation and behavior of unmodified and modified GNPs the distribution of GNPs and their zeta potential were determined.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GD106%2F09%2FH035" target="_blank" >GD106/09/H035: Multiscale design of advanced materials</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Víceúrovňový design pokrokových materiálů, sborník doktorské konference 2012

  • ISBN

    9788087434062

  • ISSN

  • e-ISSN

  • Number of pages

    8

  • Pages from-to

    147-154

  • Publisher name

    Ústav fyziky materiálů AV ČR, v. v. i.

  • Place of publication

    Brno

  • Event location

    Brno

  • Event date

    Jan 1, 2012

  • Type of event by nationality

    CST - Celostátní akce

  • UT code for WoS article