Impedimetric Aptasensor for Thrombin Recognition Based on CD Support

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00060299" target="_blank" >RIV/00216224:14310/12:00060299 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/12:PU99108
Result on the web
<a href="http://dx.doi.org/10.1002/elan.201200041" target="_blank" >http://dx.doi.org/10.1002/elan.201200041</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elan.201200041" target="_blank" >10.1002/elan.201200041</a>

Result language
angličtina
Original language name
Impedimetric Aptasensor for Thrombin Recognition Based on CD Support
Original language description
We report an aptamer biosensing array for thrombin detection by measuring the electrochemical impedance upon aptamer-protein formation at the surface of CD-trodes (GCDTs) in the presence of the redox couple [Fe(CN)6]3-/4-. GCDTs are fabricated from recordable compact discs that contain a fine gold layer. The biosensor is constructed by self-assembling of a thiol-modified thrombin binding aptamer (TBA) onto a GCDT surface. The sensor reveals good ligand specificity, recognition in a wide range of thrombin concentrations from 20 nM to 1 mu M with a limit of detection of 5 nM.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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