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Toxic Megacolon Burdened with COVID-19 Coinfection — Worsening of an Unfavorable Diagnosis: A Single-Center Retrospective Study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157489" target="_blank" >RIV/00098892:_____/22:10157489 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15110/22:73617110

  • Result on the web

    <a href="https://www.mdpi.com/2075-1729/12/10/1545" target="_blank" >https://www.mdpi.com/2075-1729/12/10/1545</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/life12101545" target="_blank" >10.3390/life12101545</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Toxic Megacolon Burdened with COVID-19 Coinfection — Worsening of an Unfavorable Diagnosis: A Single-Center Retrospective Study

  • Original language description

    Introduction: This study primarily sought to evaluate the risk factors for toxic megacolon development and treatment outcomes in Clostridium difficile-positive COVID-19 patients, secondarily to determining predictors of survival. Methods: During the second COVID-19 wave (May 2020 to May 2021), we identified 645 patients with confirmed COVID-19 infection, including 160 patients with a severe course in the intensive care unit. We selected patients with Clostridium difficile infection (CDI) (31 patients) and patients with toxic megacolon (9 patients) and analyzed possible risk factors. Results: Patients who developed toxic megacolon had a higher incidence (without statistical significance, due to small sample size) of cancer and chronic obstructive pulmonary disease, a higher proportion of them required antibiotic treatment using cephalosporins or penicillins, and there was a higher rate of extracorporeal circulation usage. C-reactive protein (CRP) and interleukin-6 values showed significant differences between the groups (CRP [median 126 mg/L in the non-toxic megacolon cohort and 237 mg/L in the toxic megacolon cohort; p = 0.037] and interleukin-6 [median 252 ng/L in the group without toxic megacolon and 1127 ng/L in those with toxic megacolon; p = 0.016]). As possible predictors of survival, age, presence of chronic venous insufficiency, cardiac disease, mechanical ventilation, and infection with Candida species were significant for increasing the risk of death, while corticosteroid and cephalosporin treatment and current Klebsiella infection decreased this risk. Conclusion: More than ever, the COVID-19 pandemic required strong up-to-date treatment recommendations to decrease the rate of serious in-hospital complications. Further studies are required to evaluate the interplay between COVID-19 and CDI/toxic megacolon.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30212 - Surgery

Result continuities

  • Project

    <a href="/en/project/NU22-C-113" target="_blank" >NU22-C-113: Effect of COVID-19 pandemic on surgical care for patients with solid tumors of gastrointestinal tract in the Czech Republic:</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Life

  • ISSN

    2075-1729

  • e-ISSN

    2075-1729

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    12

  • Pages from-to

    1545

  • UT code for WoS article

    000873008500001

  • EID of the result in the Scopus database

    2-s2.0-85140619384