What are the real associations of homeostasis model assessment (HOMA) with body mass index and age?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157747" target="_blank" >RIV/00098892:_____/22:10157747 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/22:43905102 RIV/00216208:11110/22:10447626 RIV/61989592:15120/22:73613306 RIV/61988987:17110/22:A2302HJ4 RIV/61989592:15110/22:73613306

Result on the web

<a href="https://journals.viamedica.pl/endokrynologia_polska/article/view/87880" target="_blank" >https://journals.viamedica.pl/endokrynologia_polska/article/view/87880</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/EP.a2022.0031" target="_blank" >10.5603/EP.a2022.0031</a>

Result language

angličtina

Original language name

What are the real associations of homeostasis model assessment (HOMA) with body mass index and age?

Original language description

Introduction: Insulin resistance (IR), a key pathogenesis mechanism of metabolic disorders, can be tested using homeostatic model assessment (HOMA). HOMA-IR quantifies peripheral tissue IR, whereas HOMA-β determines insulin secretion. The cross-sectional study aimed to examine non-linear associations of HOMA indices with age when adjusting for body mass index (BMI), and thus to investigate the indices' ability to reflect the real development of glucose metabolism disorders over time. Material and methods: The sample comprised 3406 individuals without diabetes mellitus (DM) divided into those with normal glucose metabolism (NGT, n = 1947) and prediabetes (n = 1459) after undergoing biochemical analyses. Polynomial multiple multivariate regression was applied to objectify associations of HOMA with both age and BMI. Results: Mean values of HOMA-IR and HOMA-β in individuals with NGT were 1.5 and 82.8, respectively, while in prediabetics they were 2.2 and 74.3, respectively. The regression proved an inverse non-linear dependence of pancreatic β dysfunction, expressed by HOMA-β, on age, but did not prove a dependence on age for HOMA-IR. Both indices were positively, statistically significantly related to BMI, with a unit increase in BMI representing an increase in HOMA-IR by 0.1 and in HOMA-β by 3.2. Conclusions: The mean values of HOMA indices showed that, compared with NGT, prediabetes is associated with more developed IR but lower insulin secretion. Both HOMA-IR and HOMA-β are predicted by BMI, but only HOMA-β is predicted by age. HOMA indices can reflect non-linear, closer-to-reality dependencies on age, which in many epidemiological studies are simplified to linear ones. The assessment of glucose metabolism using HOMA indices is beneficial for the primary prevention of IR and thus DM.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endokrynologia Polska

ISSN

0423-104X

e-ISSN

—

Volume of the periodical

73

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

7

Pages from-to

736-742

UT code for WoS article

000852058200001

EID of the result in the Scopus database

2-s2.0-85137219044