Total and high-molecular-weight adiponectin levels and prediction of insulin resistance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F18%3AE0107611" target="_blank" >RIV/00843989:_____/18:E0107611 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/18:73588588

Result on the web

<a href="https://journals.viamedica.pl/endokrynologia_polska/article/view/56885" target="_blank" >https://journals.viamedica.pl/endokrynologia_polska/article/view/56885</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/EP.a2018.0035" target="_blank" >10.5603/EP.a2018.0035</a>

Result language

angličtina

Original language name

Total and high-molecular-weight adiponectin levels and prediction of insulin resistance

Original language description

Introduction: Adiponectin is a peptide secreted by adipocytes; its reduction is associated with obesity-related disorders, including insulin resistance (IR). The study analysed levels of total adiponectin and its high-molecular-weight (HMW) oligomer in a group of metabolically healthy adults and in patients with type 2 diabetes mellitus (T2DM) to evaluate these levels as potential predictors of the presence of IR. Materials and methods: The study comprised 269 metabolically healthy adults and 300 patients with T2DM. Anthropometric and biochemical indices were measured, including total and HMW adiponectin levels; the Homeostatic Model Assessment of IR (HOMA-IR) index was calculated, and logistic regression analysis was used to predict the presence of IR. Results: In healthy individuals, both total and HMW adiponectin levels were significantly higher than in diabetic patients. Total and HMW adiponectin levels were moderately correlated with the HOMA-IR index. Logistic regression analysis showed that increased levels of both total adiponectin (odds ratio [OR] 0.598, 95% confidence interval [CI] 0.483–0.723) and the HMW form (OR 0.360, 95% CI 0.242–0.511) are protective factors for the development of IR. The cut-off levels were 4.22 mg/L for total adiponectin and 2.75 mg/L for HMW adiponectin. The results are valid for middle-aged European adults. Conclusions: Adiponectin levels below the indicated cut-offs may predict a potential risk for the development of IR.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endokrynologia Polska

ISSN

0423-104X

e-ISSN

—

Volume of the periodical

69

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

6

Pages from-to

375-380

UT code for WoS article

000444730200004

EID of the result in the Scopus database

2-s2.0-85055836105