Total and high molecular weight adiponectin levels and prediction of cardiovascular risk in diabetic patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F15%3AE0104729" target="_blank" >RIV/00843989:_____/15:E0104729 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2015/545068" target="_blank" >http://dx.doi.org/10.1155/2015/545068</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/545068" target="_blank" >10.1155/2015/545068</a>
Alternative languages
Result language
angličtina
Original language name
Total and high molecular weight adiponectin levels and prediction of cardiovascular risk in diabetic patients
Original language description
The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11098" target="_blank" >NT11098: Epidemiological study of adipose tissue proteins importance in relation to insulin resistance</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of endocrinology
ISSN
1687-8337
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
n. Article ID 545068
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"p. 1-6"
UT code for WoS article
000354692600001
EID of the result in the Scopus database
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