S100B protein as a biomarker and predictor in traumatic brain injury
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F24%3A10158022" target="_blank" >RIV/00098892:_____/24:10158022 - isvavai.cz</a>
Result on the web
<a href="https://biomed.papers.upol.cz/artkey/bio-202404-0003_s100b-protein-as-a-biomarker-and-predictor-in-traumatic-brain-injury.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202404-0003_s100b-protein-as-a-biomarker-and-predictor-in-traumatic-brain-injury.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2023.025" target="_blank" >10.5507/bp.2023.025</a>
Alternative languages
Result language
angličtina
Original language name
S100B protein as a biomarker and predictor in traumatic brain injury
Original language description
Objectives: To determine the prognostic potential of S100B protein in patients with craniocerebral injury, correlation between S100B protein and time, selected internal diseases, body habitus, polytrauma, and season. Methods: We examined the levels of S100B protein in 124 patients with traumatic brain injury (TBI). Results: The S100B protein level 72 h after injury and changes over 72 h afterwards are statistically significant for prediction of a good clinical condition 1 month after injury. The highest sensitivity (81.4%) and specificity (83.3%) for the S100B protein value after 72 h was obtained for a cut-off value of 0.114. For the change after 72 h, that is a decrease in S100B value, the optimal cut-off is 0.730, where the sum of specificity (76.3%) and sensitivity (54.2%) is the highest, or a decrease by 0.526 at the cut-off value, where sensitivity (62.5%) and specificity (62.9%) are more balanced. The S100B values were the highest at baseline; S100B value taken 72 h after trauma negatively correlated with GCS upon discharge or transfer (r=-0.517, P<0.0001). We found no relationship between S100B protein and hypertension, diabetes mellitus, BMI, or season when the trauma occurred. Changes in values and a higher level of S100B protein were demonstrated in polytraumas with a median of 1.070 (0.042; 8.780) μg/L compared to isolated TBI with a median of 0.421 (0.042; 11.230) μg/L. Conclusion: S100B protein level with specimen collection 72 h after trauma can be used as a complementary marker of patient prognosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
1804-7521
Volume of the periodical
168
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
288-294
UT code for WoS article
001028019400001
EID of the result in the Scopus database
2-s2.0-85191240446