Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00051865" target="_blank" >RIV/00216224:14110/11:00051865 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/11:#0001232

Result on the web

<a href="http://dx.doi.org/10.3109/02699052.2010.541895" target="_blank" >http://dx.doi.org/10.3109/02699052.2010.541895</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/02699052.2010.541895" target="_blank" >10.3109/02699052.2010.541895</a>

Result language

angličtina

Original language name

Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children

Original language description

The aim of the study was to determine whether serum levels of hyperphosphorylated neurofilament NF-H correlate with severity of brain injury in children. Methods: Forty-nine patients with traumatic brain injury (TBI) were enrolled into the prospective study. Venous blood samples were taken after admission and every 24 h for a maximum of 6 consecutive days. Serum NF-H concentrations were quantified by enzyme-linked immunosorbent assay. The outcome was evaluated 6 months after TBI using Glasgow Outcome Scale (GOS) in all patients. Results: The quantitative level of pNF-H remained significantly higher in patients with poor outcome (GOS = 1) in comparison with the other patients for the 2nd-4th day (p = 0.027; p = 0.019; p = 0.01). Levels of pNF-H were significantly higher in patients with diffuse axonal injury on initial CT scan (p = 0.004). Normal levels pNF-H in the paediatric population are unknown. Objective ROC analysis was identification of optimal cut-offs of proteins for predictio

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain Injury

ISSN

0269-9052

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

221-226

UT code for WoS article

000288101800008

EID of the result in the Scopus database

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