In vivo assessment of TiO2 based wear nanoparticles in periprosthetic tissues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F24%3A10158660" target="_blank" >RIV/00098892:_____/24:10158660 - isvavai.cz</a>
Alternative codes found
RIV/44994575:_____/24:10001858 RIV/61989592:15110/24:73627526 RIV/61989592:15310/24:73627526
Result on the web
<a href="https://link.springer.com/article/10.1007/s00216-024-05320-x" target="_blank" >https://link.springer.com/article/10.1007/s00216-024-05320-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00216-024-05320-x" target="_blank" >10.1007/s00216-024-05320-x</a>
Alternative languages
Result language
angličtina
Original language name
In vivo assessment of TiO2 based wear nanoparticles in periprosthetic tissues
Original language description
A multimodal approach combining inductively coupled plasma mass spectrometry (ICP-MS), single-particle ICP-MS (spICP-MS), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDS) and Raman spectroscopy enabled a deeper insight into the balance between total titanium (Ti), the soluble titanium fraction and titanium dioxide based particle fraction levels in periprosthetic tissues collected from patients undergoing revision surgery. Hydrofluoric acid usage in the sample digestion allowed for complete digestion of TiO2 particles, thus enabling accurate estimation of total Ti levels. The TiO2 fraction represents 38–94% of the titanium load in the six samples where particles were detected, and the fraction is present mainly in samples from patients with aseptically loosened total hip arthroplasty. Further attention was given to this fraction determining the elemental composition, particle count, particle size and modification of TiO2. The spICP-MS analysis confirmed the presence of the TiO2-derived (nano)particles (NPs) with a 39- to 187-nm median size and particle count up to 2.3 × 10 11 particles per gram of tissue. On top of that, the SEM-EDS confirmed the presence of the TiO2 nanoparticles with 230-nm median size and an anatase crystal phase was determined by Raman spectroscopy. This study presents a novel multimodal approach for TiO2 particle determination and characterization in tissue samples and is the first in vivo study of this character.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Analytical and Bioanalytical Chemistry
ISSN
1618-2642
e-ISSN
1618-2650
Volume of the periodical
416
Issue of the periodical within the volume
16
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
3785-3796
UT code for WoS article
001220842400001
EID of the result in the Scopus database
2-s2.0-85192574593