Advances in ICP-MS-Based Nanoparticle Characterization: Techniques and Challenges in Biological Sample Analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73633635" target="_blank" >RIV/61989592:15310/25:73633635 - isvavai.cz</a>
Result on the web
<a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jssc.70259?getft_integrator=clarivate&src=getftr&utm_source=clarivate" target="_blank" >https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jssc.70259?getft_integrator=clarivate&src=getftr&utm_source=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jssc.70259" target="_blank" >10.1002/jssc.70259</a>
Alternative languages
Result language
angličtina
Original language name
Advances in ICP-MS-Based Nanoparticle Characterization: Techniques and Challenges in Biological Sample Analysis
Original language description
The increasing use of engineered nanoparticles (NPs) in consumer and biomedical products has raised concern over their potential accumulation, transformation, and toxicity in biological systems. Accurate analytical methods are essential to detect, characterize, and quantify NPs in complex biological matrices. Inductively coupled plasma mass spectrometry (ICP-MS) has emerged as a leading technique due to its high sensitivity, elemental selectivity, and quantitative capabilities. This review critically evaluates recent advances (from January 2020 onward) in ICP-MS-based methods for analysis of NPs in biological samples. Two main strategies are discussed: single-particle ICP-MS (spICP-MS) and hyphenated techniques coupled to ICP-MS. spICP-MS allows direct determination of particle size, concentration, and metal content at environmentally relevant levels. It is the most widely used approach and is therefore examined in greater detail, with attention to extraction procedures, particle types, sample matrices, and inherent limitations. Advances in laser ablation spICP-MS for tissue imaging and spatially resolved NPs detection are also covered. Methods using hyphenated techniques, such as hydrodynamic chromatography, size-exclusion chromatography, capillary electrophoresis, Taylor dispersion analysis, and field-flow fractionation, are increasingly employed to address limitations spICP-MS. These approaches can provide enhanced insight into particle size distributions, aggregation behavior, and interactions with complex sample matrices. This review offers a comparative evaluation of both single-particle and hyphenated methods, discussing their respective advantages and limitations. Emphasis is placed on the complementarity of these techniques and how their combined use can offer a more complete understanding of NPs' fate in biological systems.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF SEPARATION SCIENCE
ISSN
1615-9306
e-ISSN
1615-9314
Volume of the periodical
48
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
23
Pages from-to
"e70259-1"-"e70259-23"
UT code for WoS article
001568594000001
EID of the result in the Scopus database
2-s2.0-105015493996