Environmental Factors in the Etiology of Mental Disorders in the Czech Republic: Final Results

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159208" target="_blank" >RIV/00098892:_____/25:10159208 - isvavai.cz</a>

Result on the web

<a href="https://www.dovepress.com/environmental-factors-in-the-etiology-of-mental-disorders-in-the-cze-2-peer-reviewed-fulltext-article-NDT" target="_blank" >https://www.dovepress.com/environmental-factors-in-the-etiology-of-mental-disorders-in-the-cze-2-peer-reviewed-fulltext-article-NDT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S498992" target="_blank" >10.2147/NDT.S498992</a>

Result language

angličtina

Original language name

Environmental Factors in the Etiology of Mental Disorders in the Czech Republic: Final Results

Original language description

We researched the environmental factors in the etiology of mental disorders in the Czech Republic. A novel avenue of research assesses the sum of an individual’s environmental exposures to create their polyenviromic risk score (PERS). An individual’s PERS is calculated as follows: first, the odds ratio for each evidence-based environmental risk factor is obtained based on literature; next, the presence or absence of each environmental risk factor is determined for the participant and the log of the odds ratio for each environmental risk factor is multiplied by either 1 (risk factor is present) or 0 (risk factor is absent); these values are summed and then divided by the total number of risk factors assessed. In this way, environmental risk factors are aggregated. This attitude was created by Padmanabhan et al, and we only adopted this mathematical procedure. The aim of our study was to investigate the lifetime presence of both environmental risk factors and protective variables in patients with psychosis or a mood disorder (PSYCH+MOOD), compared with patients with an anxiety disorder (ANX). We used this group configuration because the genetic backgrounds of psychoses and mood disorders overlap, but are distinct from anxiety disorders. We tested the main hypothesis that the PERS and polyenviromic protective score differ between the PSYCH +MOOD and ANX groups. This hypothesis is based on the presumption that heritability is higher in psychoses and mood disorders compared with anxiety disorders. Our preliminary results which included 94 patients with psychosis or a mood disorder and 52 with anxiety disorder, were published in Neuropsychiatric Disease and Treatment. Neither the polyenviromic risk score nor the polyenviromic protective score differed significantly between the PSYCH+MOOD and ANX groups (p = 0.149 and p = 0.466, respectively). Additionally, we accumulated more research data to increase the validity of our results. We used the same methods to assess participants who were either hospitalized or treated at the outpatient office of the Department of Psychiatry, University Hospital at Hradec Kralove or Olomouc, Czech Republic. We maintained the same inclusion and exclusion criteria.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychiatric Disease and Treatment

ISSN

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e-ISSN

1178-2021

Volume of the periodical

21

Issue of the periodical within the volume

March

Country of publishing house

NZ - NEW ZEALAND

Number of pages

5

Pages from-to

541-545

UT code for WoS article

001678503400001

EID of the result in the Scopus database

2-s2.0-105000104480