Prognostic impact of immune phenotype in oral squamous cell carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159333" target="_blank" >RIV/00098892:_____/25:10159333 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00141926 RIV/61989592:15110/25:73635898 RIV/00159816:_____/25:00082345

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1368837525003975?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1368837525003975?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.oraloncology.2025.107568" target="_blank" >10.1016/j.oraloncology.2025.107568</a>

Result language

angličtina

Original language name

Prognostic impact of immune phenotype in oral squamous cell carcinoma

Original language description

Background: In oral squamous cell carcinoma (OSCC), the current staging system fails to reliably identify high-risk patients, and potential biomarkers improving the prognostic, and predictive stratification of OSCC are sought. Due to the importance of tumor immune microenvironment in the development and progression of cancer, here we investigated the prognostic impact of immune phenotypes in OSCC. Methods: The study included 119 OSCC patients treated by curative surgery. Based on the extent and spatial distribution of TILs in hematoxylin and eosin-staining, the tumors were classified as immune-excluded, immune-inflamed, and immune-desert. The prognostic significance and clinicopathological correlations of immune phenotypes were investigated, immunohistochemically detected PD-L1 expression levels were correlated with immune phenotypes. Results: Immune-desert and immune-inflamed phenotypes significantly correlated with lymph node metastasis, higher stage, grade, and perineural invasion. A higher incidence of local recurrence was demonstrated in patients with immune-inflamed phenotype. PD-L1 expression levels correlated with immune phenotypes, with the highest expression levels in inflamed tumors. In Kaplan-Meier analysis, inferior survival rates were demonstrated in immune-desert and immune-inflamed OSCC (p &lt; 0.0001). Cox regression showed an independent negative prognostic impact of both immune-inflamed and immune-desert phenotypes on disease-free (HR 5.327 and 4.256, respectively), disease-specific (HR 12.09 and 4.337), and overall survival (HR 4.502 and 4.300). Conclusions: Our findings support that the histological evaluation of tumor immune phenotype might provide significant information on OSCC hazard discrimination, prognostication, and treatment decisions. The study identified immune-desert and immune-inflamed OSCC phenotypes associated with worse prognosis reflecting the lack of pre-existing anti-tumor immunity or immunosuppressive tumor immune microenvironment.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oral Oncology

ISSN

1368-8375

e-ISSN

1879-0593

Volume of the periodical

168

Issue of the periodical within the volume

September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

107568

UT code for WoS article

001542479700002

EID of the result in the Scopus database

2-s2.0-105011869537