The Role of Neopterin and Interleukin-6 Detection in Saliva and Plasma in Oral and Oropharyngeal Cancer Patients: A Prospective Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159405" target="_blank" >RIV/00098892:_____/25:10159405 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00143744 RIV/61989592:15110/25:73635913
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/cre2.70202" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/cre2.70202</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cre2.70202" target="_blank" >10.1002/cre2.70202</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Neopterin and Interleukin-6 Detection in Saliva and Plasma in Oral and Oropharyngeal Cancer Patients: A Prospective Study
Original language description
Objectives: The incidence of oral and oropharyngeal cancer is continually rising and affects increasingly younger patients. Consequently, many studies focus on early diagnosis using appropriate biomarkers. Neopterin and interleukin-6 (IL-6) are promising predictive and prognostic markers of immune response activation, both systemic and local, due to the anatomical proximity of malignancies to the salivary glands. Material and Methods: We collected oral fluid samples from 50 patients before and after the surgical resection of squamous cell carcinoma of the oral cavity and oropharynx. Additionally, blood samples were withdrawn from 20 of these patients and levels of neopterin and IL-6 were estimated using ELISA commercial kits. All gathered data were subsequently statistically analyzed for evaluation and compared to values from a control group of healthy individuals. Results: In patients with oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC), there was a significant decrease in neopterin and IL-6 levels in saliva following the surgical removal of the malignancy. These postoperative levels approached those of the control group. There was no significant decrease in neopterin and IL-6 levels in plasma. Conclusion: Detection of neopterin and IL-6 in saliva is a reliable diagnostic method for early detection of OSCC and its recurrence, as well as for monitoring therapeutic success, compared to plasma. Neopterin and IL-6 appear to be promising prognostic and predictive markers of the disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30208 - Dentistry, oral surgery and medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Dental Research
ISSN
2057-4347
e-ISSN
2057-4347
Volume of the periodical
11
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
"e70202"
UT code for WoS article
001554420800001
EID of the result in the Scopus database
2-s2.0-105013662953