Distinct cell state ecosystems for nodular lymphocyte-predominant Hodgkin lymphoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159441" target="_blank" >RIV/00098892:_____/25:10159441 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41467-025-63339-9" target="_blank" >https://www.nature.com/articles/s41467-025-63339-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-025-63339-9" target="_blank" >10.1038/s41467-025-63339-9</a>
Alternative languages
Result language
angličtina
Original language name
Distinct cell state ecosystems for nodular lymphocyte-predominant Hodgkin lymphoma
Original language description
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and few studies have comprehensively investigated the immune microenvironment and rare lymphocyte-predominant (LP) cells. Here we develop a NLPHL specific lymphocyte-predominant ecotype (LPE) model to identify 34 distinct cell states across 14 cell types that co-occur within 3 LPEs for 171 cases. LPE1 and LPE2 were characterized by immunosuppressive microenvironments with high expression of B2M on LP cells, CD8 T-cell exhaustion, immune checkpoint genes expressed by follicular T-cells, and an improved freedom from progression compared to LPE3 in training (n = 109, with 65% LPE1/2) and validation cohorts (n = 62, with 61% LPE1/2). We validate the co-occurrence and co-localization of cell states using spatial transcriptomics. Protein expression of HLA-I and HLA-II on LP cells and SSTR2 on dendritic cells was predictive of LPE1 (C-statistic=0.69), LPE2 (C-statistic=0.79), and LPE3 (C-statistic=0.60). This study establishes a clinically relevant biologic categorization for NLPHL.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NU22-03-00182" target="_blank" >NU22-03-00182: Circulating Tumor DNA and its Prognostic Impact in Hodgkin Lymphoma</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
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e-ISSN
2041-1723
Volume of the periodical
16
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
16
Pages from-to
8473
UT code for WoS article
001582555200017
EID of the result in the Scopus database
2-s2.0-105017401642