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MicroRNAs Regulate p21 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F12%3A%230000950" target="_blank" >RIV/00159816:_____/12:#0000950 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1002/stem.1108" target="_blank" >http://dx.doi.org/10.1002/stem.1108</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/stem.1108" target="_blank" >10.1002/stem.1108</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    MicroRNAs Regulate p21 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells

  • Original language description

    Studies of human embryonic stem cells (hESCs) commonly describe the nonfunctional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). Importantly, p21 mRNA is clearly presentand upregulated after the DDR in hESCs, but p21 protein is not detectable. In this article, we provide evidence that expression of p21 protein is directly regulated by the microRNA (miRNA) pathway under standard culture conditions and after DNA damage. The DDR in hESCs leads to upregulation of tens of miRNAs, including hESC-specific miRNAs such as those of the miR-302 family, miR-371-372 family, or C19MC miRNA cluster. Most importantly, we show that the hESC-enriched miRNA family miR-302 (miR-302a, miR-302b, miR-302c, and miR-302d) directly contributes to regulation of p21 expression in hESCs and, thus, demonstrate a novel function for miR-302s in hESCS. The described mechanism elucidates the role of miRNAs in regulation of important mo

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    STEM CELLS

  • ISSN

    1066-5099

  • e-ISSN

  • Volume of the periodical

    30

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    1362-1372

  • UT code for WoS article

    000305477000005

  • EID of the result in the Scopus database