Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060539" target="_blank" >RIV/00159816:_____/13:00060539 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1159/000353915" target="_blank" >http://dx.doi.org/10.1159/000353915</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000353915" target="_blank" >10.1159/000353915</a>
Alternative languages
Result language
angličtina
Original language name
Acidic pH of Tumor Microenvironment Enhances Cytotoxicity of the Disulfiram/Cu2+ Complex to Breast and Colon Cancer Cells
Original language description
Background: Resistance of cancer cells to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The drug resistance of tumor cells can be significantly modified by specific features of tumor microenvironnnent, such as oxygen depletion (hypoxia), glucose/energy deprivation and acidosis. Methods:The effects of acidic tumor-like microenvironment on cytotoxicity of antabuse (disulfiram, DSF)/ Cu2+ complexes to MCF-7 breast carcinoma and HT-29 colon carcinoma cells were studied. Results: We show that acidic pH significantly potentiates toxicity of DSF/Cu2+ complex to breast and colon cancer cells. This phenomenon is associated with changes in cell metabolism, altered Akt kinase and NFKB activity and increased reactive oxygenspecies production. Conclusion: Specific pH of tumor microenvironnnent enhances cytotoxicity of DSF/Cu2+ to breast and colon cancer cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemotherapy
ISSN
0009-3157
e-ISSN
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Volume of the periodical
59
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
112-120
UT code for WoS article
000325833000006
EID of the result in the Scopus database
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