Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00065625" target="_blank" >RIV/00216224:14310/13:00065625 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1159/000353915" target="_blank" >http://dx.doi.org/10.1159/000353915</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000353915" target="_blank" >10.1159/000353915</a>
Alternative languages
Result language
angličtina
Original language name
Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells
Original language description
A resistance of cancer cells to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The drug-resistance of tumor cells can be significantly modified by specific features of tumor microenvironment, such as oxygen depletion (hypoxia), glucose/energy deprivation and acidosis. The effects of acidic tumor-like microenvironment on cytotoxicity of antabuse (disulfiram)/Cu2+ complexes to MCF-7 breast carcinoma and HT-29 colon carcinoma cells were studied. We show that acidic pH significantly potentiates toxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. This phenomenon is associated with changes in cell metabolism, altered Akt kinase and NFkappaB activities and increased reactive oxygen species production.Conclusion: Specific pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ to breast and colon cancer cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CHEMOTHERAPY
ISSN
0009-3157
e-ISSN
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Volume of the periodical
2013
Issue of the periodical within the volume
59
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
112-120
UT code for WoS article
000325833000006
EID of the result in the Scopus database
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