The Relationship Between Leptin and Ventilatory Control in Heart Failure

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060563" target="_blank" >RIV/00159816:_____/13:00060563 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1071916413012049" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1071916413012049</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cardfail.2013.10.004" target="_blank" >10.1016/j.cardfail.2013.10.004</a>

Result language
angličtina
Original language name
The Relationship Between Leptin and Ventilatory Control in Heart Failure
Original language description
Background: Increased serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluatedthe relationship of circulating leptin concentration with exercise ventilation in HF patients. Methods and Results: Fifty-eight consecutive ambulatory HF patients were stratified by quintiles of leptin concentration, with a lowest quintile of mean leptinconcentration of 1.8 +/- 8.9 ng/mL and a highest of 33.3 +/- 30.3 ng/mL. Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in the lowest (46 +/- 6 vs 34 +/- 4; P < .01) as well as in the highest (38 +/- 8 vs 34 +/- 4; P < .05) leptin concentration quintiles compared with the reference middle quintile. Multiple regression analysis adjusted for confounders such as age, sex, and body mass index showed leptin concentration to be independently inversely correlated to
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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