Sex differences in leptin modulate ventilation in heart failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066794" target="_blank" >RIV/00159816:_____/17:00066794 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00098218

Result on the web

<a href="http://dx.doi.org/10.1016/j.hrtlng.2017.01.008" target="_blank" >http://dx.doi.org/10.1016/j.hrtlng.2017.01.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.hrtlng.2017.01.008" target="_blank" >10.1016/j.hrtlng.2017.01.008</a>

Result language

angličtina

Original language name

Sex differences in leptin modulate ventilation in heart failure

Original language description

Background: Leptin modulates ventilation and circulating levels are higher in normal women than men. Objectives: The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration. Methods: Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration. Results: Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p &gt; 0.05). Leptin concentration was lower (10.3 +/- 10 vs. 25.3 +/- 16 ng/mL; p &lt; 0.01) and peak exercise ventilatory efficiency (V-E/VCO2) was higher (43 +/- 10 vs. 36 +/- 5; p &lt; 0.01) in men. Leptin concentration was associated with peak exercise V-E/VCO2 (b = -0.35; F = 5.6; p = 0.02). Conclusion: Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive. (C) 2017 Published by Elsevier Inc.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Heart &amp; Lung

ISSN

0147-9563

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

187-191

UT code for WoS article

000403197500010

EID of the result in the Scopus database

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