Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070541" target="_blank" >RIV/00159816:_____/19:00070541 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00109665 RIV/65269705:_____/19:00070541

Result on the web

<a href="https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0215997&type=printable" target="_blank" >https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0215997&type=printable</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0215997" target="_blank" >10.1371/journal.pone.0215997</a>

Result language

angličtina

Original language name

Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome

Original language description

Introduction Measurement of ventilatory efficiency, defined as minute ventilation per unit carbon dioxide production (V-E/VCO2), by cardiopulmonary exercise testing (CPET) has been proposed as a screen for hyperventilation syndrome (HVS). However, increased V-E/VCO2 may be associated with other disorders which need to be distinguished from HVS. A more specific marker of HVS by CPET would be clinically useful. We hypothesized ventilatory control during exercise is abnormal in patients with HVS. Methods Patients who underwent CPET from years 2015 through 2017 were retrospectively identified and formed the study group. HVS was defined as dyspnea with respiratory alkalosis (pH &gt;7.45) at peak exercise with absence of acute or chronic respiratory, heart or psychiatric disease. Healthy patients were selected as controls. For comparison the Student t-test or Mann-Whitney U test were used. Data are summarized as mean +/- SD or median (IQR); p&lt;0.05 was considered significant. Results Twenty-nine patients with HVS were identified and 29 control subjects were selected. At rest, end-tidal carbon dioxide (PETCO2) was 27 mmHg (25-30) for HVS patients vs. 30 mmHg (28-32); in controls (p = 0.05). At peak exercise PETCO2 was also significantly lower (27 +/- 4 mmHg vs. 35 +/- 4 mmHg; p&lt; 0.01) and V-E/VCO2 higher ((38 (35-43) vs. 31 (27-34); p&lt; 0.01)) in patients with HVS. In contrast to controls, there were minimal changes of PETCO2 (0.50 +/- 5.26 mmHg vs. 6.2 +/- 4.6 mmHg; p&lt; 0.01) and V-E/VCO2 ((0.17 (-4.24-6.02) vs. -6.6 (-11.4-(-2.8)); p&lt; 0.01)) during exercise in patients with HVS. The absence of V-E/VCO2 and PETCO2 change during exercise was specific for HVS (83% and 93%, respectively). Conclusion Absence of V-E/VCO2 and PETCO2 change during exercise may identify patients with HVS.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10700 - Other natural sciences

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

"e0215997"

UT code for WoS article

000465223900061

EID of the result in the Scopus database

2-s2.0-85065236491