Modulation of Ventilatory Reflex Control by Cardiac Resynchronization Therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00061636" target="_blank" >RIV/00159816:_____/15:00061636 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.cardfail.2014.12.013" target="_blank" >http://dx.doi.org/10.1016/j.cardfail.2014.12.013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cardfail.2014.12.013" target="_blank" >10.1016/j.cardfail.2014.12.013</a>

Result language
angličtina
Original language name
Modulation of Ventilatory Reflex Control by Cardiac Resynchronization Therapy
Original language description
Heart failure (HF) is characterized by heightened sensitivity of the CO2 chemoreflex and the ergoreflex which promote increased ventilatory drive manifest as increased minute ventilation per volume of expired CO2 (VE/VCO2). The aims of this study were toevaluate the effects of cardiac resynchronization therapy (CRT) on carbon dioxide (CO2) chemosensitivity and the arterial CO2 setpoint. METHODS AND RESULTS: Consecutive HF patients (n=35) who underwent clinically-indicated CRT were investigated by cardiopulmonary exercise testing and CO2 chemosensitivity by a rebreathe method before and 4-6 months post-CRT. Pre- and post-CRT measures were compared by either paired t-test or Wilcoxon test. Decreased peak VE/VCO2 (44+-10 vs. 40+-8; p<0.01), CO2 chemosensitivity (2.2+-1.1 vs. 1.7+-0.8 L/min/mmHg; p=0.04) and increased peak end-tidal CO2 (29+-5 vs. 31+-5 mmHg; p<0.01) were also observed post-CRT. Multivariate analysis adjusted for age and gender showed the decrease of peak VE/VCO2 from pre
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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