Myeloperoxidase induces the priming of platelets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060645" target="_blank" >RIV/00159816:_____/13:00060645 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00394796 RIV/00216224:14310/13:00081894
Result on the web
<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.014" target="_blank" >http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.014" target="_blank" >10.1016/j.freeradbiomed.2013.04.014</a>
Alternative languages
Result language
angličtina
Original language name
Myeloperoxidase induces the priming of platelets
Original language description
The release of myeloperoxidase (MPO) from polymorphonuclear neutrophils is a hallmark of vascular inflammation and contributes to the pathogenesis of vascular inflammatory processes. However, the effects of MPO on platelets as a contributory mechanism invascular inflammatory diseases remain unknown. Thus, MPO interaction with platelets and its effects on platelet function were examined. First, dose-dependent binding of MPO (between 1.7 and 13.8 nM) to both human and mouse platelets was observed. This was in direct contrast to the absence of MPO in megakaryocytes. MPO was localized both on the surface of and inside platelets. Cytoskeleton inhibition did not prevent MPO localization inside the three-dimensional platelet structure. MPO peroxidase activity was preserved upon the MPO binding to platelets. MPO sequestered in platelets catabolized NO, documented by the decreased production of NO (on average, an approximately 2-fold decrease). MPO treatment did not affect the viability of pla
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Free radical biology and medicine
ISSN
0891-5849
e-ISSN
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Volume of the periodical
61
Issue of the periodical within the volume
April
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
357-369
UT code for WoS article
000320687300035
EID of the result in the Scopus database
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