Red blood cells serve as intravascular carriers of myeloperoxidase

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061113" target="_blank" >RIV/00159816:_____/14:00061113 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/14:00431577
Result on the web
<a href="http://dx.doi.org/10.1016/j.yjmcc.2014.06.009" target="_blank" >http://dx.doi.org/10.1016/j.yjmcc.2014.06.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yjmcc.2014.06.009" target="_blank" >10.1016/j.yjmcc.2014.06.009</a>

Result language
angličtina
Original language name
Red blood cells serve as intravascular carriers of myeloperoxidase
Original language description
Myeloperoxidase (MPO) is a heme enzyme abundantly expressed in polymorphonuclear neutrophils. MPO is enzymatically capable of catalyzing the generation of reactive oxygen species (ROS) and the consumption of nitric oxide (NO). Thus MPO has both potent microbicidal and, upon binding to the vessel wall, pro-inflammatory properties. Interestingly, MPO - a highly cationic protein - has been shown to bind to both endothelial cells and leukocyte membranes. Given the anionic surface charge of red blood cells,we investigated binding of MPO to erythrocytes. Red blood cells (RBCs) derived from patients with elevated MPO plasma levels showed significantly higher amounts of MPO by flow cytometry and ELISA than healthy controls. Heparin-induced MPO-release from patient-derived RBCs was significantly increased compared to controls. Ex vivo experiments revealed dose and time dependency for MPO-RBC binding, and immunofluorescence staining as well as confocal microscopy localized MPO-RBC interaction t
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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