Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00060944" target="_blank" >RIV/00159816:_____/14:00060944 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1378/chest.12-2914" target="_blank" >http://dx.doi.org/10.1378/chest.12-2914</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1378/chest.12-2914" target="_blank" >10.1378/chest.12-2914</a>
Alternative languages
Result language
angličtina
Original language name
Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure
Original language description
Background: Leptin-deficient animals hyperventilate. Leptin expression by adipocytes is attenuated by atrial natriuretic peptide (ANP). Increased circulating natriuretic peptides (NPs) are associated with an increased risk of central sleep apnea (CSA). This study tested whether serum leptin concentration is inversely correlated to NP concentration and decreased in patients with heart failure (HF) and CSA. Methods: Subjects with HF (N = 29) were studied by measuring leptin, NPs, CO2 chemosensitivity (Delta minute ventilation [(V) over dotE]/Delta partial pressure of end-tidal CO2 [PETCO2]), and ventilatory efficiency ((V) over dotE/CO2 output [(V) over dotO(2)]) and were classified as CSA or no sleep-disordered breathing by polysomnography. CSA was defined as a central apnea-hypopnea index >= 15. The Student t test, Mann-Whitney U test, and logistic regression were used for analysis, and data were summarized as mean +/- SD; P < .05 was considered significant. Results: Subjects with CSA
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chest
ISSN
0012-3692
e-ISSN
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Volume of the periodical
145
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
72-78
UT code for WoS article
000329966300020
EID of the result in the Scopus database
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