Stable Phenotype and Function of Immortalized Lin(-)Sca-1(+) Cardiac Progenitor Cells in Long-Term Culture: A Step Closer to Standardization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061040" target="_blank" >RIV/00159816:_____/14:00061040 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1089/scd.2013.0305" target="_blank" >http://dx.doi.org/10.1089/scd.2013.0305</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/scd.2013.0305" target="_blank" >10.1089/scd.2013.0305</a>

Result language
angličtina
Original language name
Stable Phenotype and Function of Immortalized Lin(-)Sca-1(+) Cardiac Progenitor Cells in Long-Term Culture: A Step Closer to Standardization
Original language description
Putative cardiac progenitor cells (CPCs) have been identified in the myocardium and are regarded as promising candidates for cardiac cell-based therapies. Although two distinct populations of CPCs reached the clinical setting, more detailed studies are required to portray the optimal cell type and therapeutic setting to drive robust cell engraftment and cardiomyogenesis after injury. Owing to the scarcity of the CPCs and the need for reproducibility, the generation of faithful cellular models would facilitate this scrutiny. Here, we evaluate whether immortalized Lin(-)Sca-1(+) CPCs (iCPC(Sca-1)) represent their native-cell counterpart, thereby constituting a robust in vitro model system for standardized investigation in the cardiac field. iCPC(Sca-1) were established in vitro as plastic adherent cells endowed with robust self-renewal capacity while preserving a stable phenotype in long-term culture. iCPC(Sca-1) differentiated into cardiomyocytic-, endothelial-, and smooth muscle-like c
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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