Relationship of mismatch repair proteins and survivin in colon polyps and carcinomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061067" target="_blank" >RIV/00159816:_____/14:00061067 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/14:A1501B6G
Result on the web
<a href="http://dx.doi.org/10.1016/j.acthis.2014.04.005" target="_blank" >http://dx.doi.org/10.1016/j.acthis.2014.04.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.acthis.2014.04.005" target="_blank" >10.1016/j.acthis.2014.04.005</a>
Alternative languages
Result language
angličtina
Original language name
Relationship of mismatch repair proteins and survivin in colon polyps and carcinomas
Original language description
Mismatch repair genes (MMR) play an essential role in DNA repair. MMR mutations predominantly in MLH1, MSH2, MSH6, PMS2, and rarely in PMS1, may cause the production of abnormally short or inactivated proteins. The antiapoptotic protein survivin functions in the inhibition of apoptosis, regulation of cell division and also enhances angiogenesis. Both MMRP and survivin are considered to be powerful prognostic parameters. This study was designed to determine the relationship between MMRP and survivin in colon lesions. The study included 113 cases of colon carcinoma and 51 cases of colon polyps. Survivin expression and MMRP status were assessed by immunohistochemistry. In each section, expression, intensity of immunostaining and percentage of labeled cells were analyzed. In carcinomas, immunoreaction was detected in 100/113 cases for MLH1 (88.5%), 112/113 cases for MSH2 (99.1%), 110/113 cases for MSH6 (97.3%), and 103/113 cases for PMS2 (91.2%). Survivin was shown in 47/113 cases (41.6%).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Histochemica
ISSN
0065-1281
e-ISSN
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Volume of the periodical
116
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
1007-1014
UT code for WoS article
000341478400003
EID of the result in the Scopus database
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