The Significance Of (CA)n Tandem Repeat in GABA(A) Beta-3 Subunit Gene in Tinnitus Manifestation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00062497" target="_blank" >RIV/00159816:_____/14:00062497 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/14:00080148

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Significance Of (CA)n Tandem Repeat in GABA(A) Beta-3 Subunit Gene in Tinnitus Manifestation

Original language description

Study aim: Study objective was to explore associations between manifestation of tinnitus, auditory evoked potentials and genetic background of gamma-aminobutyric acid type A (GABA(A) receptors) to support the disinhibited feedback hypothesis of tinnitusgeneration. Materials and methods: A population of 131 patients was assessed for severity of hearing loss, quantification of tinnitus, mid-latency responses (MLR) and brainstem auditory evoked potentials (BAEP), and (CA)n tandem repeat polymorphism in GABA(A) Beta-3 subunit gene to establish any correlation with manifestation of tinnitus. Results: It was observed that tinnitus score correlates with V/III amplitude ratio in BAEP (R = 0.22, p < 0.001) and with mean pure tone audiometry (PTA) threshold (R= 0.22, p = 0.017). Analysis of the MLR results showed a significant correlation between the PA wave amplitude and the tinnitus score (R = 0.31-0.37; p < 0.001). MLR result analysis showed no statistically significant correlation between

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NS10101" target="_blank" >NS10101: Genetic aspects of the cisplatin induced ototoxicity - the prospective association study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

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Volume of the periodical

77

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

473-478

UT code for WoS article

000339709800010

EID of the result in the Scopus database

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