Polymorphisms of NMDA receptor, DRD2 receptor, GABA-A receptor and electrophysiologic variations found in BAEP and MLR in relation to tinnitus manifestation preliminary report.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00018998" target="_blank" >RIV/00216224:14110/04:00018998 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Polymorphisms of NMDA receptor, DRD2 receptor, GABA-A receptor and electrophysiologic variations found in BAEP and MLR in relation to tinnitus manifestation preliminary report.

Original language description

Prospective study of 50 patients demonstrate the associations between tinnitus manifestation (multiple data acquired by help of a tinnitus questionnaire) emotional lability, and Taq I polymorphism of the DRD-2, three single nucleotide polymorphism in GRIN2A subunit of the NMDA receptor and CA repeat in GABRB3 subunit of the GABA-A receptor and changes of amplitude in BAEP and MLR response waveforms which can signalize the desinhibition of the central auditory pathways. The statistically significant correlation between the tinnitus score and the V/III amplitude ratios at intensities 110 (p=0,002) and 100 dB peSPL (p=0,025) has been found. The amplitude of Pa wave of MLR response correlates significantly with tinnitus score as well (p=0.006-0.05), Thereis also a statistically significant dependency between the V/III ratio and the amplitude of Pa wave (p=0,046 at 110 dB). The genetic analysis shows the difference of the tinnitus score according to genotypes of polymorphism GRIN2a MSP (le

Czech name

Polymorfismus NMDA receptoru, DRD2 receptoru, GABA-A receptoru a variabilita elektrofyziologických odpovdí BAEP a MLR ve vztahu k manifestaci tinnitu - pedbžná zpráva

Czech description

Prospektivní studie 50 pacient prokazující asociace mezi manifestací tinnitu (data získaná z dotazníku), emoní labilitou, Taq I polymorfismem DRD2 receptoru, 3 SN polymorfismy NMDA receptoru a CA repetitivní sekvencí GABA-A receptoru a zmnami v odpovdíchBAEP a MLR, které mohou signalizovat desinhibici. Byl nalezen statisticky signifikantní vztah mezi pomrem amplitud vln V/III na intenzit 110 dB (p=0,002) a 100 dB (p=0,025), Amplituda vlny Pa korelovala rovnž s tinnitus skóre (p=0,006-0,05). Genetická analýza ukazuje margináln signifikantní rozdíl bv tinnitus skóre u polymorfismu GRIN2a MSP (p=0,07) a rozdíl v elektrofyziologických odpovdích u polymorfismu GRIN2a PST (p=0,003). Všechny testované polymorfismy byly konzistentní s Hardy-Weinbergovým ekvilibriem.

Type

D - Article in proceedings

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

—

Project

<a href="/en/project/NM7472" target="_blank" >NM7472: Electrophysiologic and genetic aspects of tinnitus</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

5th European Congress of Oto-Rhino-Laryngology, Head and Neck Surgery, Rhodos, Hellas, Sept. 11-16, 2004

ISBN

—

ISSN

—

e-ISSN

—

Number of pages

2

Pages from-to

192-193

Publisher name

C&C International

Place of publication

Rhodos

Event location

Rhodos

Event date

Sep 11, 2004

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

—